Flow cytometry measurement of the labile iron pool in human hematopoietic cells.

@article{Prus2008FlowCM,
  title={Flow cytometry measurement of the labile iron pool in human hematopoietic cells.},
  author={Eugenia Prus and Eitan Fibach},
  journal={Cytometry. Part A : the journal of the International Society for Analytical Cytology},
  year={2008},
  volume={73 1},
  pages={22-7}
}
Iron is important for many biological processes, and its deficiency or excess is involved in pathological conditions. Although most iron is firmly bound (e.g., in hemoglobin), some, the labile iron pool (LIP), is bound to low-affinity ligands. The level of LIP is regulated to meet the cell's requirements for iron but prevent excess. We describe herein a multiparameter flow cytometry procedure for measuring LIP in various human hematopoietic cells. Peripheral blood and bone marrow (BM) cells… CONTINUE READING
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Singlecell image analysis to assess ABC-transporter-mediated efflux in highly purified hematopoietic progenitors

  • HG Raaijmakers, G Van Den Bosch, J Boezeman, T De Witte, RA. Raymakers
  • Cytometry
  • 2002
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