Flow cytometry and IG/TCR quantitative PCR for minimal residual disease quantitation in acute lymphoblastic leukemia: a French multicenter prospective study on behalf of the FRALLE, EORTC and GRAALL

@article{Garand2013FlowCA,
  title={Flow cytometry and IG/TCR quantitative PCR for minimal residual disease quantitation in acute lymphoblastic leukemia: a French multicenter prospective study on behalf of the FRALLE, EORTC and GRAALL},
  author={Richard Garand and Khe{\"i}ra Beldjord and H{\'e}l{\`e}ne Cav{\'e} and Chantal Fossat and Isabelle Arnoux and Vahid Asnafi and Yves Bertrand and M L Boulland and Chantal Brouzes and Emmanuelle Clappier and Eric C M Delabesse and Thierry Fest and Francine Garnache-Ottou and Françoise Huguet and M Jacob and Emilienne Kuhlein and Sophie Marty-Gr{\`e}s and Adriana Plesa and Nelly Robillard and Murielle Roussel and Jean Tkaczuk and Herv{\'e} Dombret and Elizabeth A Macintyre and Norbert Ifrah and Marie Christine B{\'e}n{\'e} and Andr{\'e} Baruchel},
  journal={Leukemia},
  year={2013},
  volume={27},
  pages={370-376}
}
Minimal residual disease (MRD) quantification is widely used for therapeutic stratification in pediatric acute lymphoblastic leukemia (ALL). A robust, reproducible, sensitivity of at least 0.01% has been achieved for IG/TCR clonal rearrangements using allele-specific quantitative PCR (IG/TCR-QPCR) within the EuroMRD consortium. Whether multiparameter flow… CONTINUE READING