Flow cytometry analysis of T cells and continuous T-cell lines from autoimmune MRL/l mice

@article{Lewis1981FlowCA,
  title={Flow cytometry analysis of T cells and continuous T-cell lines from autoimmune MRL/l mice},
  author={Dorothy E. Lewis and Janis V. Giorgi and Noel L. Warner},
  journal={Nature},
  year={1981},
  volume={289},
  pages={298-300}
}
The study of spontaneous autoimmunity in mouse models affords an opportunity to determine the cellular basis of the immune dysregulation observed in this disease. Recently, a new mouse strain, MRL/Mp-lpr/lpr (MRL/l) has been developed1 which carries an autosomal recessive gene (lpr) that results in massive lymph node enlargement concomitant with the development of several autoantibodies1–4. The interest in this strain lies in the possibility that the defect in T-cell regulation of the immune… CONTINUE READING