Flow cytometric measurement of kinetic and equilibrium binding parameters of arginine-glycine-aspartic acid ligands in binding to glycoprotein IIb/IIIa on platelets.

Abstract

Antagonists of platelet glycoprotein IIb/IIIa (GPIIb/IIIa) represent a new therapeutic approach in inhibiting platelet aggregation, thus providing a powerful form of antithrombotic therapy. The measurement of binding of arginine-glycine-aspartic acid (RGD) peptidomimetics to GPIIb/IIIa on platelets is a key for the further understanding of ligand-receptor… (More)

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@article{Bednar1997FlowCM, title={Flow cytometric measurement of kinetic and equilibrium binding parameters of arginine-glycine-aspartic acid ligands in binding to glycoprotein IIb/IIIa on platelets.}, author={Bohumil Bednar and Matthew E. Cunningham and P A McQueney and Melissa S Egbertson and Ben C Askew and Rodney A. Bednar and George D. Hartman and Randall J. Gould}, journal={Cytometry}, year={1997}, volume={28 1}, pages={58-65} }