Flow cytometric evaluation of platelet activation in blood collected into EDTA vs. Diatube-H, a sodium citrate solution supplemented with theophylline, adenosine, and dipyridamole.

@article{Khne1995FlowCE,
  title={Flow cytometric evaluation of platelet activation in blood collected into EDTA vs. Diatube-H, a sodium citrate solution supplemented with theophylline, adenosine, and dipyridamole.},
  author={Thomas K{\"u}hne and Adriana Hornstein and John W Semple and W Chang and Victor S. Blanchette and John T. Freedman},
  journal={American journal of hematology},
  year={1995},
  volume={50 1},
  pages={40-5}
}
With platelet activation, there is modulation of platelet surface molecule expression. In flow cytometric analyses of in vivo platelet activation, results are often confounded by activation induced in vitro by the preparative procedures. It is particularly important therefore to prevent or retard platelet activation as soon as possible after withdrawal of the blood sample. Taking blood into paraformaldehyde, or fixing the cells with paraformaldehyde as soon as possible after withdrawal, has… CONTINUE READING

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