Flow cytometric evaluation of fas expression in relation to response and resistance to anthracyclines in leukemic cells.

@article{Labroille2000FlowCE,
  title={Flow cytometric evaluation of fas expression in relation to response and resistance to anthracyclines in leukemic cells.},
  author={G. Labroille and Patrice Dumain and Francis Lacombe and Françis Belloc},
  journal={Cytometry},
  year={2000},
  volume={39 3},
  pages={195-202}
}
BACKGROUND Cell chemosensitivity to cytotoxic drugs has been attributed to their ability to trigger apoptosis. The emergence of resistance in drug-exposed cells is often characterized by the appearance of drug efflux mechanisms including P-gp transport. Nevertheless, mdr1 expression may coexist with other resistance features, in particular those interfering with apoptotic signaling pathways. METHODS Leukemic cell lines cultured in a progressively toxic environment were analyzed for Fas and P… CONTINUE READING