Flow cytometric detection of total and serine 473 phosphorylated Akt.

  title={Flow cytometric detection of total and serine 473 phosphorylated Akt.},
  author={Pier Luigi Tazzari and Alessandra Cappellini and Roberta Bortul and Francesca Ricci and Anna Maria Billi and Giovanna Tabellini and R. N. Conte and Alberto Maria Martelli},
  journal={Journal of cellular biochemistry},
  volume={86 4},
The evaluation of regulatory proteins is important for biological studies and is also established as a prognostic marker for cancer diagnosis. Very recently, it has been highlighted that the serine/threonine kinase Akt plays a fundamental role in survival pathways and is also involved in the onset of resistance to anti-neoplastic drugs and ionizing radiation in cell lines derived from solid tumors. For its full activation Akt needs to be phosphorylated on Serine 473 residue. Molecules that are… CONTINUE READING


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