Flow cytometric detection of platelet-reactive antibodies and application in platelet crossmatching.

@article{Koehler1996FlowCD,
  title={Flow cytometric detection of platelet-reactive antibodies and application in platelet crossmatching.},
  author={Michael Koehler and J. Fred Dittmann and Tobias J{\"o}rg Legler and Rainer Lynen and Andreas Humpe and J. Heinrich Riggert and Helen Neumeyer and A. Pies and Simon Panzer and Wolfgang Richard Mayr},
  journal={Transfusion},
  year={1996},
  volume={36 3},
  pages={
          250-5
        }
}
BACKGROUND Alloimmunization against HLA or platelet antigens can cause refractoriness to platelet transfusions in multiply transfused patients. Crossmatching of platelet concentrates is effective in overcoming this problem. STUDY DESIGN AND METHODS A flow cytometric assay was used for simultaneous detection of lymphocyte-reactive and platelet-reactive antibodies in a single sample using fluorescein isothiocyanate-labeled anti-IgG. This assay was compared with the monoclonal antibody-specific… CONTINUE READING
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