Flow cytometric detection of accelerated telomere shortening in myelodysplastic syndromes: correlations with aetiological and clinical-biological findings.

@article{Rigolin2004FlowCD,
  title={Flow cytometric detection of accelerated telomere shortening in myelodysplastic syndromes: correlations with aetiological and clinical-biological findings.},
  author={Gian Matteo Rigolin and Matteo Giovanni Della Porta and Anna Maria Bugli and Barbara Castagnari and Endri Mauro and Letizia Zenone Bragotti and Maria Ciccone and Antonio Cuneo and Gianluigi Castoldi},
  journal={European journal of haematology},
  year={2004},
  volume={73 5},
  pages={351-8}
}
Using quantitative fluorescence in situ hybridisation and flow cytometry (flow-FISH), we investigated the biological and clinical relevance of telomere length in 55 patients affected by myelodysplastic syndromes (MDS) compared with 55 sex- and age-matched controls. We found that telomere fluorescence in MDS granulocytes, and CD34+ cells did not decline with age as in normal controls and that MDS granulocytes and CD34+ cells had significantly shorter telomeres than healthy controls. A… CONTINUE READING

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Telomere length in myelodysplastic syndromes.

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