Flow cytometric analysis of the effect of ara-C on the chronobiology of bone marrow DNA synthesis.

Abstract

Flow cytometry, a technique which allows rapid quantitation of the percentages of a cell population in the various cell cycle phases, closely duplicated the previously reported circadian rhythm for mouse bone marrow DNA synthesis. The effect of ara-C, an S phase specific anti-neoplastic drug, on this rhythm was investigated. Ara-C was shown to suppress this… (More)

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