Flow cytometric analysis of intraplatelet VASP phosphorylation for the detection of clopidogrel resistance in patients with ischemic cardiovascular diseases.

@article{Aleil2005FlowCA,
  title={Flow cytometric analysis of intraplatelet VASP phosphorylation for the detection of clopidogrel resistance in patients with ischemic cardiovascular diseases.},
  author={Boris Aleil and Catherine Ravanat and J. P. Cazenave and G Rochoux and Antoine Heitz and Christian Gachet},
  journal={Journal of thrombosis and haemostasis : JTH},
  year={2005},
  volume={3 1},
  pages={85-92}
}
Interindividual variability of the inhibitory effect of clopidogrel on platelet functions leading to clopidogrel resistance has been described in some patients with ischemic cardiovascular disease. A reliable laboratory test is therefore needed to identify patients insufficiently protected by this antiplatelet treatment. The phosphorylation of vasodilator-stimulated phosphoprotein (VASP), an intraplatelet actin regulatory protein, is dependent on the level of activation of the platelet P2Y12… CONTINUE READING

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