Flow cytometric analysis of changes in cytoskeletal proteins during platelet destruction and activation using a monoclonal antibody against platelet myosin.

Abstract

We developed a new monoclonal antibody directed against platelet myosin (NNKY6-19). Using this antibody, we analyzed platelet cytoskeletal changes related to stimulation with thrombin and to long-term storage. Immunoelectron microscopy showed increased binding of NNKY6-19 to pseudopods and the open canalicular system during treatment with thrombin (0.1 U/ml… (More)

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Cite this paper

@article{Yamaguchi1993FlowCA, title={Flow cytometric analysis of changes in cytoskeletal proteins during platelet destruction and activation using a monoclonal antibody against platelet myosin.}, author={K. Yamaguchi and Shuhei Nomura and Hiroshi Kido and Takaya Kawakatsu and Tsutomu Fukuroi and M. Suzuki and Kunihiro Hamamoto and Mutsumasa Yanabu and Takayuki Kokawa and Katsuaki Yasunaga}, journal={American journal of hematology}, year={1993}, volume={44 2}, pages={106-11} }