Flow cytometric analysis of DNA aneuploidy in primary and metastatic human solid tumors.

@article{Frankfurt1984FlowCA,
  title={Flow cytometric analysis of DNA aneuploidy in primary and metastatic human solid tumors.},
  author={Oskar S. Frankfurt and Harry K. Slocum and Youcef M. Rustum and Susan G. Arbuck and Zlatko P. Pavelic and Nicholas Petrelli and Robert P. Huben and Edson J. Pontes and William R. Greco},
  journal={Cytometry},
  year={1984},
  volume={5 1},
  pages={71-80}
}
DNA histograms were measured by flow cytometry for 656 human solid tumors (365 primary and 291 metastatic). The proportion of aneuploid cells in cell suspensions obtained by mechanical disaggregation was significantly higher than those obtained after enzymatic disaggregation (collagenase + DNAse) of the same tumor. A strong correlation was observed between the values of DNA-indices measured after staining with propidium iodide and with 4',-6-diamidino-2-phenylindole (r = 0.97). Aneuploid cells… CONTINUE READING

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