Flow control valves for analytical microfluidic chips without mechanical parts based on thermally responsive monolithic polymers.

  title={Flow control valves for analytical microfluidic chips without mechanical parts based on thermally responsive monolithic polymers.},
  author={Congyao Yu and Senol Mutlu and Ponnambalam Ravi Selvaganapathy and Carlos H. Mastrangelo and Franti{\vs}ek {\vS}vec and Jean M. J. Fr{\'e}chet},
  journal={Analytical chemistry},
  volume={75 8},
Monolithic plugs of poly(N-isopropylacrylamide) cross-linked with 5% methylenebisacrylamide have been prepared by photoinitiated polymerization within the channel of a microfluidic device. The volume change associated with the polymer phase transition at its lower critical solution temperature of 32 degrees C allows both the rapid swelling and the deswelling of the monoliths enabling the polymer to close or open the channel as it functions as a nonmechanical valve. Thermoelectric elements… 
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Advances in Polymer Science; Responsive Gels: Volume Transitions II