Flow control valves for analytical microfluidic chips without mechanical parts based on thermally responsive monolithic polymers.

@article{Yu2003FlowCV,
  title={Flow control valves for analytical microfluidic chips without mechanical parts based on thermally responsive monolithic polymers.},
  author={Congyao Yu and Senol Mutlu and Ponnambalam Ravi Selvaganapathy and Carlos H. Mastrangelo and Franti{\vs}ek {\vS}vec and Jean M. J. Fr{\'e}chet},
  journal={Analytical chemistry},
  year={2003},
  volume={75 8},
  pages={
          1958-61
        }
}
Monolithic plugs of poly(N-isopropylacrylamide) cross-linked with 5% methylenebisacrylamide have been prepared by photoinitiated polymerization within the channel of a microfluidic device. The volume change associated with the polymer phase transition at its lower critical solution temperature of 32 degrees C allows both the rapid swelling and the deswelling of the monoliths enabling the polymer to close or open the channel as it functions as a nonmechanical valve. Thermoelectric elements… 
A Polymer-Based Microfluidic Platform Featuring On-Chip Actuated Hydrogel Valves for Disposable Applications
present a highly functional polymer-based microfluidic device for disposable applications. This device is plastic injection molded and exhibits three levels of functionality: 1) fluidic interconnects
Self-Actuated, Thermo-Responsive Hydrogel Valves for Lab on a Chip
TLDR
The paper describes the construction and characterization of the hydrogel valves and their application for flow control, sample and reagent metering, sample distribution into multiple analysis paths, and the sealing of a polymerase chain reaction (PCR) reactor to suppress bubble formation.
A Thermally Responsive PDMS Composite and Its Microfluidic Applications
This paper describes a novel composite actuator for controlled liquid actuation in microsystems which is based on a thermally responsive elastomer. The composite actuator consists of expandable
Light-actuated high pressure-resisting microvalve for on-chip flow control based on thermo-responsive nanostructured polymer.
A simple light-actuated microvalve using a quartz halogen illuminator with tungsten filament was introduced to manipulate flow path effectively in micro-total analysis systems, which reduces system
Micropumps operated by swelling and shrinking of temperature-sensitive hydrogels.
TLDR
Two types of polymeric micropumps based on the temperature-sensitive hydrogel poly(N-isopropylacrylamide) are described, which are intended for low performance applications and can operate in two modes: peristaltic or pulsatile.
High-pressure on-chip mechanical valves for thermoplastic microfluidic devices.
TLDR
A facile method enabling the integration of elastomeric valves into rigid thermoplastic microfluidic chips is described, and proportional valve operation is demonstrated using a multi-valve chemical gradient generator fabricated in cyclic olefin polymer.
Fluid steering in a microfluidic chip by means of thermally responsive phospholipids
Abstract The viscosity of aqueous phospholipid preparations comprised of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) and 1,2-dihexanoyl-sn-glycero-3-phosphocholine (DHPC) increases with
Microfluidic actuators based on temperature-responsive hydrogels
The concept of using stimuli-responsive hydrogels to actuate fluids in microfluidic devices is particularly attractive, but limitations, in terms of spatial resolution, speed, reliability and
Hydrogel Microvalves as Control Elements for Parallelized Enzymatic Cascade Reactions in Microfluidics
TLDR
The integration of thermoresponsive poly(N-isopropylacrylamide) (PNiPAAm) microvalves into PDMS-on-glass microfluidic devices for the control of parallelized enzyme-catalyzed cascade reactions with immobilized catalysts is shown.
...
1
2
3
4
5
...

References

Advances in Polymer Science; Responsive Gels: Volume Transitions II