Flow-activated transport events along the nephron

  title={Flow-activated transport events along the nephron},
  author={Tong Wang},
  journal={Current Opinion in Nephrology and Hypertension},
  • Tong Wang
  • Published 2006
  • Medicine
  • Current Opinion in Nephrology and Hypertension
  • Purpose of reviewIt is well recognized that an increase in glomerular filtration rate leads to an increase in fluid, Na+ and HCO3− absorption in proximal tubules; however, underlying mechanisms of this modulation have not been delineated. This review provides an update of flow-activated transport events along the nephron. Transporters, flow-sensors and secondary messengers that may modulate flow are also discussed. Recent findingsWe have demonstrated that both NHE3 and H-ATPase activities are… CONTINUE READING
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