Flotillins Interact with PSGL-1 in Neutrophils and, upon Stimulation, Rapidly Organize into Membrane Domains Subsequently Accumulating in the Uropod

@article{Rossy2009FlotillinsIW,
  title={Flotillins Interact with PSGL-1 in Neutrophils and, upon Stimulation, Rapidly Organize into Membrane Domains Subsequently Accumulating in the Uropod},
  author={J{\'e}r{\'e}mie Rossy and Dominique Schlicht and Britta Engelhardt and Verena Niggli},
  journal={PLoS ONE},
  year={2009},
  volume={4},
  pages={2549 - 2556}
}
BACKGROUND Neutrophils polarize and migrate in response to chemokines. Different types of membrane microdomains (rafts) have been postulated to be present in rear and front of polarized leukocytes and disruption of rafts by cholesterol sequestration prevents leukocyte polarization. Reggie/flotillin-1 and -2 are two highly homologous proteins that are ubiquitously enriched in detergent resistant membranes and are thought to shape membrane microdomains by forming homo- and hetero-oligomers. It… CONTINUE READING