Floor Plate and Netrin-1 Are Involved in the Migration and Survival of Inferior Olivary Neurons

  title={Floor Plate and Netrin-1 Are Involved in the Migration and Survival of Inferior Olivary Neurons},
  author={E. Bloch-Gallego and F. Ezan and M. Tessier-Lavigne and C. Sotelo},
  journal={The Journal of Neuroscience},
  pages={4407 - 4420}
  • E. Bloch-Gallego, F. Ezan, +1 author C. Sotelo
  • Published 1999
  • Medicine, Biology
  • The Journal of Neuroscience
  • During their circumferential migration, the nuclei of inferior olivary neurons translocate within their axons until they reach the floor plate where they stop, although their axons have already crossed the midline to project to the contralateral cerebellum. Signals released by the floor plate, including netrin-1, have been implicated in promoting axonal growth and chemoattraction during axonal pathfinding in different midline crossing systems. In the present study, we report experiments that… CONTINUE READING

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