Flock house virus induces apoptosis by depletion of Drosophila inhibitor-of-apoptosis protein DIAP1.

@article{Settles2008FlockHV,
  title={Flock house virus induces apoptosis by depletion of Drosophila inhibitor-of-apoptosis protein DIAP1.},
  author={Erik W Settles and Paul D. Friesen},
  journal={Journal of virology},
  year={2008},
  volume={82 3},
  pages={1378-88}
}
The molecular mechanisms by which RNA viruses induce apoptosis and apoptosis-associated pathology are not fully understood. Here we show that flock house virus (FHV), one of the simplest RNA viruses (family, Nodaviridae), induces robust apoptosis of permissive Drosophila Line-1 (DL-1) cells. To define the pathway by which FHV triggers apoptosis in this model invertebrate system, we investigated the potential role of Drosophila apoptotic effectors during infection. Suggesting the involvement of… CONTINUE READING
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