Floating-mucoadhesive beads of clarithromycin for the treatment of Helicobacter pylori infection.

@article{Gattani2010FloatingmucoadhesiveBO,
  title={Floating-mucoadhesive beads of clarithromycin for the treatment of Helicobacter pylori infection.},
  author={Surendra Ganeshlal Gattani and Pankaj Jayantilal Savaliya and Veena Shailendra Belgamwar},
  journal={Chemical & pharmaceutical bulletin},
  year={2010},
  volume={58 6},
  pages={782-7}
}
An objective of the present study was to develop alginate/hydroxypropyl methylcellulose (HPMC) based floating-mucoadhesive beads of clarithromycin to provide prolonged contact time of antibiotic to treat stomach ulcer. Floating-mucoadhesive beads were prepared and characterized for in vitro performance followed by investigation of ex vivo study in albino-wistar rats. Beads were prepared by ionic gelation technique where calcium chloride used as gelating agent and incorporated liquid paraffin… CONTINUE READING