Flipping the switch: tools for detecting small molecule inhibitors of staphylococcal virulence

@inproceedings{Quave2014FlippingTS,
  title={Flipping the switch: tools for detecting small molecule inhibitors of staphylococcal virulence},
  author={Cassandra Leah Quave and Alexander R. Horswill},
  booktitle={Front. Microbiol.},
  year={2014}
}
Through the expression of the accessory gene regulator quorum sensing cascade, Staphylococcus aureus is able to produce an extensive array of enzymes, hemolysins and immunomodulators essential to its ability to spread through the host tissues and cause disease. Many have argued for the discovery and development of quorum sensing inhibitors (QSIs) to augment existing antibiotics as adjuvant therapies. Here, we discuss the state-of-the-art tools that can be used to conduct screens for the… CONTINUE READING
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