Flipping the cyclooxygenase (Ptgs) genes reveals isoform-specific compensatory functions.

@article{Li2018FlippingTC,
  title={Flipping the cyclooxygenase (Ptgs) genes reveals isoform-specific compensatory functions.},
  author={Xinzhi Li and Liudmila L. Mazaleuskaya and Chong Kah Yuan and Laurel L. Ballantyne and Hu Meng and William Levi Smith and Garret A. FitzGerald and Colin D. Funk},
  journal={Journal of lipid research},
  year={2018},
  volume={59 1},
  pages={
          89-101
        }
}
Two prostaglandin (PG) H synthases encoded by Ptgs genes, colloquially known as cyclooxygenase (COX)-1 and COX-2, catalyze the formation of PG endoperoxide H2, the precursor of the major prostanoids. To address the functional interchangeability of these two isoforms and their distinct roles, we have generated COX-2>COX-1 mice whereby Ptgs2 is knocked in to the Ptgs1 locus. We then "flipped" Ptgs genes to successfully create the Reversa mouse strain, where knock-in COX-2 is expressed… CONTINUE READING
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