Flightless I is a focal adhesion-associated actin-capping protein that regulates cell migration.

@article{Mohammad2012FlightlessII,
  title={Flightless I is a focal adhesion-associated actin-capping protein that regulates cell migration.},
  author={Ibrahim Mohammad and Pamma D Arora and Yeganeh Naghibzadeh and Yongqiang Wang and Jeff Li and Wendall Mascarenhas and Paul A. Janmey and John F. Dawson and C A McCulloch},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2012},
  volume={26 8},
  pages={3260-72}
}
The role of adhesion-associated actin-binding proteins in cell migration is not well defined. In mouse fibroblasts we screened for focal adhesion-associated proteins that were isolated with collagen-coated beads and detected by tandem mass spectrometry. We identified flightless I (FliI) as an actin-binding protein in focal adhesion fractions, which was verified by immunoblotting. By confocal microscopy most FliI was distributed throughout the cytosol and in focal adhesions. By sedimentation… CONTINUE READING