Fli-1 inhibits collagen type I production in dermal fibroblasts via an Sp1-dependent pathway.

@article{CzuwaraLadykowska2001Fli1IC,
  title={Fli-1 inhibits collagen type I production in dermal fibroblasts via an Sp1-dependent pathway.},
  author={Joanna Czuwara-Ladykowska and Fumiaki Shirasaki and Pascale Jackers and Dennis K. Watson and Maria Trojanowska},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 24},
  pages={
          20839-48
        }
}
Fibrosis is characterized by the excessive deposition of extracellular matrix (ECM), especially collagen. Because Ets factors are implicated in physiological and pathological ECM remodeling, the aim of this study was to investigate the role of Ets factors in collagen production. We demonstrate that the expression of collagenous proteins and collagen alpha2(I) (COL1A2) mRNA was inhibited following stable transfection of Fli-1 in dermal fibroblasts. Subsequent analysis of the COL1A2 promoter… CONTINUE READING

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