Flexible use of nuclear import pathways by HIV-1.

  title={Flexible use of nuclear import pathways by HIV-1.},
  author={K. Lee and Z. Ambrose and T. D. Martin and I. Oztop and Alok Mulky and J. G. Julias and N. Vandegraaff and J. G. Baumann and R. Wang and W. Yuen and T. Takemura and Kenneth Shelton and I. Taniuchi and Y. Li and J. Sodroski and D. Littman and J. Coffin and S. Hughes and D. Unutmaz and A. Engelman and V. Kewalramani},
  journal={Cell host & microbe},
  volume={7 3},
  • K. Lee, Z. Ambrose, +18 authors V. Kewalramani
  • Published 2010
  • Biology, Medicine
  • Cell host & microbe
  • HIV-1 replication requires transport of nascent viral DNA and associated virion proteins, the retroviral preintegration complex (PIC), into the nucleus. Too large for passive diffusion through nuclear pore complexes (NPCs), PICs use cellular nuclear transport mechanisms and nucleoporins (NUPs), the NPC components that permit selective nuclear-cytoplasmic exchange, but the details remain unclear. Here we identify a fragment of the cleavage and polyadenylation factor 6, CPSF6, as a potent… CONTINUE READING
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