Flexible use of nuclear import pathways by HIV-1.

@article{Lee2010FlexibleUO,
  title={Flexible use of nuclear import pathways by HIV-1.},
  author={Kyeongeun Lee and Zandrea Ambrose and Thomas David Martin and Ilker Oztop and Alok Mulky and John G. Julias and Nick Vandegraaff and J{\"o}rg G. Baumann and Rui Bo Wang and Wendy Yuen and Taichiro Takemura and Kenneth Shelton and Ichiro Taniuchi and Yuan Xiang Li and Joseph Sodroski and Dan R. Littman and John M Coffin and Stephen H. Hughes and Derya Unutmaz and Alan N. Engelman and Vineet N Kewalramani},
  journal={Cell host & microbe},
  year={2010},
  volume={7 3},
  pages={
          221-33
        }
}
HIV-1 replication requires transport of nascent viral DNA and associated virion proteins, the retroviral preintegration complex (PIC), into the nucleus. Too large for passive diffusion through nuclear pore complexes (NPCs), PICs use cellular nuclear transport mechanisms and nucleoporins (NUPs), the NPC components that permit selective nuclear-cytoplasmic exchange, but the details remain unclear. Here we identify a fragment of the cleavage and polyadenylation factor 6, CPSF6, as a potent… CONTINUE READING
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