Flexible heteroarotinoids (Flex-Hets) exhibit improved therapeutic ratios as anti-cancer agents over retinoic acid receptor agonists

@article{Benbrook2005FlexibleH,
  title={Flexible heteroarotinoids (Flex-Hets) exhibit improved therapeutic ratios as anti-cancer agents over retinoic acid receptor agonists},
  author={Doris Mangiaracina Benbrook and Scott A. Kamelle and Suresh B. Guruswamy and Stan A. Lightfoot and Teresa L. Rutledge and Natalie S. Gould and Bethany N. Hannafon and Samuel Terence Dunn and K. Darrell Berlin},
  journal={Investigational New Drugs},
  year={2005},
  volume={23},
  pages={417-428}
}
The anti-cancer activities and toxicities of retinoic acid (RA) and synthetic retinoids are mediated through nuclear RA receptors (RARs) and retinoid X receptors (RXRs) that act as transcription factors. Heteroarotinoids (Hets), which contain a heteroatom in the cyclic ring of an arotinoid structure, exhibit similar anti-cancer activities, but reduced toxicity in vivo, in comparison to parent retinoids and RA. A new class of Flexible Hets (Flex-Hets), which contain 3-atom urea or thiourea… CONTINUE READING

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