Flexibility in repression and cooperativity by KorB of broad host range IncP-1 plasmid RK2.

@article{Bingle2005FlexibilityIR,
  title={Flexibility in repression and cooperativity by KorB of broad host range IncP-1 plasmid RK2.},
  author={Lewis E H Bingle and Donia P Macartney and Ana{\"i}s Fantozzi and Susan E. Manzoor and Christopher M. Thomas},
  journal={Journal of molecular biology},
  year={2005},
  volume={349 2},
  pages={302-16}
}
KorB, encoded by plasmid RK2, belongs to the ParB family of active partitioning proteins. It binds to 12 operators on the RK2 genome and was previously known to repress promoters immediately adjacent to operators O(B)1, O(B)10 and O(B)12 (proximal) or up to 154 bp away (distal) from O(B)2, O(B)9 and O(B)11. To achieve strong repression, KorB requires a cooperative interaction with one of two other plasmid-encoded repressors, KorA or TrbA. Reporter gene assays were used in this study to test… CONTINUE READING

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