Flesinoxan shows antidepressant activity in a DRL 72-s screen

@article{Hest2005FlesinoxanSA,
  title={Flesinoxan shows antidepressant activity in a DRL 72-s screen},
  author={Annemieke van Hest and Marlies Van Drimmelen and Berend Olivier},
  journal={Psychopharmacology},
  year={2005},
  volume={107},
  pages={474-479}
}
Schedules which selectively reinforce low rates of responding (DRL, differential reinforcement of low rate) distinguish between antidepressants and other types of drugs. In a DRL schedule a subject is required to pause for a specified minimum period of time between two consecutive responses in order to obtain a reinforcer. The dependent variables are rate of responding and rate of reinforcement. Response patterns of rats treated with clinically effective antidepressant drugs such as imipramine… Expand
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