Flesinoxan, a 5-HT1A receptor agonist/alpha 1-adrenoceptor antagonist, lowers intraocular pressure in NZW rabbits.

@article{Chidlow2001FlesinoxanA5,
  title={Flesinoxan, a 5-HT1A receptor agonist/alpha 1-adrenoceptor antagonist, lowers intraocular pressure in NZW rabbits.},
  author={Glyn Chidlow and Alexander Cupido and Jos{\'e} Melena and Neville N Osborne},
  journal={Current eye research},
  year={2001},
  volume={23 2},
  pages={144-53}
}
PURPOSE alpha1-Adrenoceptor antagonists and 5-HT1A receptor agonists reduce intraocular pressure (IOP) in the rabbit. The aims of this study were firstly, to determine the IOP-lowering effects of flesinoxan and selected other hybrid 5-HT1A receptor agonists/alpha1-adrenoceptor antagonists, and secondly, to investigate the mechanism of action of the IOP response to flesinoxan. METHODS IOP and total outflow facility were measured in rabbits after administration of hybrid drugs. Inositol… CONTINUE READING

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