Fleeting Activation of Ionotropic Glutamate Receptors Sensitizes Cortical Neurons to Complement Attack

  title={Fleeting Activation of Ionotropic Glutamate Receptors Sensitizes Cortical Neurons to Complement Attack},
  author={Zhi-qi Xiong and James O. McNamara},
Insidious attack of cortical neurons by complement has been implicated in Alzheimer's and other neurodegenerative diseases. Excitotoxicity, triggered by excessive activation of glutamate receptors, has been implicated in neuronal death following diverse insults, including ischemia and seizures. Clinical studies suggested that a minimal excitotoxic insult might sensitize neurons to complement attack. We found that fleeting activation of ionotropic glutamate receptors sensitizes neurons but not… CONTINUE READING
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