Flecainide Test in Brugada Syndrome: A Reproducible but Risky Tool

@article{Gasparini2003FlecainideTI,
  title={Flecainide Test in Brugada Syndrome: A Reproducible but Risky Tool},
  author={Maurizio Gasparini and Silvia Giuliana Priori and Massimo Mantica and Carlo Napolitano and Paola Galimberti and Carlo Ceriotti and Stefano Simonini},
  journal={Pacing and Clinical Electrophysiology},
  year={2003},
  volume={26}
}
GASPARINI, M., et al.: Flecainide Test in Brugada Syndrome: A Reproducible but Risky Tool. The flecainide test is widely used in Brugada syndrome. However, its reproducibility and safety remain ill‐defined. This study included 22 patients (18 men, mean age 34 years). Mutations in the SCN5A gene were found in eight patients. Two patients had aborted sudden cardiac death, 8 had syncope/presyncope, and 12 were asymptomatic. The ECG was diagnostic in 19 patients and suggestive in 3. At baseline, 21… 

ORAL FLECAINIDE IS NOT SENSITIVE ENOUGH TO RULE OUT BRUGADA-SYNDROME

Different Brugada challenge tests have different sensitivities in the diagnosis of BS and IV procainamide is more sensitive than oral Flecainide and the latter cannot be used solely to rule out BS.

Response to intravenous ajmaline: a retrospective analysis of 677 ajmaline challenges.

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Electrocardiographic and clinical parameters were identified to predict patients' response to ajmaline and guide the clinician in which setting an aj maline challenge is an appropriate diagnostic step.

Brugada Syndrome

This review provides an overview of the clinical, genetic, molecular, and cellular aspects of the Brugada syndrome, incorporating the results of two recent consensus conferences.

Brugada syndrome in children - Stepping into unchartered territory

The epidemiology, genetics, and pathogenesis of Brugada syndrome is discussed, and established standards and new innovations in the diagnosis, prognostication, risk stratification, and management of BrS are discussed.

The Brugada Syndrome.

A syndrome consisting of syncopal episodes and/or (resuscitated) sudden death in patients with a structurally normal heart and a characte ristic electrocardiogram (ECG) displaying a pattern resembling a right bundle branch block with ST segment elevation in leads V1 to V3, which has been linked to the sudden infant death syndrome and to the SUDS by showing that the electrocardsiogram and mutations are the same as in Brugada syndrome.

Clinical profile and genetic basis of Brugada syndrome in the Chinese population.

Chinese patients with Brugada syndrome who are symptomatic have a high likelihood of arrhythmia recurrence, whereas asymptomatic patients enjoy a good short-term prognosis.
...

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An ECG showing right bundle-branch block and ST-segment elevation in the right precordial leads is a marker of malignant ventricular arrhythmias and sudden death.