Flaxseed inhibits metastasis and decreases extracellular vascular endothelial growth factor in human breast cancer xenografts.

@article{Dabrosin2002FlaxseedIM,
  title={Flaxseed inhibits metastasis and decreases extracellular vascular endothelial growth factor in human breast cancer xenografts.},
  author={Charlotta Dabrosin and Jianmin Chen and Linda J Wang and Lilian U. Thompson},
  journal={Cancer letters},
  year={2002},
  volume={185 1},
  pages={31-7}
}
Angiogenesis is important in tumor growth, progression and metastatic dissemination. Vascular endothelial growth factor (VEGF) is one key factor in promotion of breast cancer angiogenesis. VEGFs are bioactive in the extracellular space where they become available to the endothelial cells. Phytoestrogens such as lignans have been shown to alter breast cancer incidence and be cancer-protective in rats. We show that supplementation of 10% flaxseed, the richest source of mammalian lignans, to nude… CONTINUE READING

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