Flavopiridol-induced apoptosis is mediated through up-regulation of E2F1 and repression of Mcl-1.

@article{Ma2003FlavopiridolinducedAI,
  title={Flavopiridol-induced apoptosis is mediated through up-regulation of E2F1 and repression of Mcl-1.},
  author={Yihong Ma and W. Douglas Cress and Eric B. Haura},
  journal={Molecular cancer therapeutics},
  year={2003},
  volume={2 1},
  pages={73-81}
}
Flavopiridol treatment can lead to apoptosis via a mechanism that has been associated with down-regulation of Mcl-1. Likewise, recent studies from our laboratory demonstrated that E2F1 leads to transcriptional repression of Mcl-1 and subsequently apoptosis. Given the ability of cyclin/cyclin-dependent kinase 2 antagonists to kill transformed cells, we surmised that flavopiridol may stabilize E2F1 and enhance apoptosis via repression of Mcl-1. Here we demonstrate that flavopiridol is associated… CONTINUE READING

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