Flavopiridol causes early mitochondrial damage in chronic lymphocytic leukemia cells with impaired oxygen consumption and mobilization of intracellular calcium.

@article{Hussain2008FlavopiridolCE,
  title={Flavopiridol causes early mitochondrial damage in chronic lymphocytic leukemia cells with impaired oxygen consumption and mobilization of intracellular calcium.},
  author={S. P. Akbar Hussain and David E. Lucas and Amy J. Johnson and Thomas H S Lin and Alan P Bakaletz and Vinh X Dang and Serge Viatchenko-Karpinski and Amy S. Ruppert and John C. Byrd and Periannan Kuppusamy and Elliott D Crouser and Michael R Grever},
  journal={Blood},
  year={2008},
  volume={111 6},
  pages={3190-9}
}
Effective administration of flavopiridol in advanced-stage chronic lymphocytic leukemia (CLL) is often associated with early biochemical evidence of tumor cell lysis. Previous work using other cell types showed that flavopiridol impacts mitochondria, and in CLL cells flavopiridol down-regulates the mitochondrial protein Mcl-1. We therefore investigated mitochondrial structure and function in flavopiridol-treated CLL patient cells and in the lymphoblastic cell line 697 using concentrations and… CONTINUE READING