Flavopiridol Inhibits TGF-β-Stimulated Biglycan Synthesis by Blocking Linker Region Phosphorylation and Nuclear Translocation of Smad2

@article{Rostam2018FlavopiridolIT,
  title={Flavopiridol Inhibits TGF-$\beta$-Stimulated Biglycan Synthesis by Blocking Linker Region Phosphorylation and Nuclear Translocation of Smad2},
  author={M. A. Rostam and Aravindra Shajimoon and D. Kamato and P. Mitra and T. Piva and Robel Getachew and Yingnan Cao and W. Zheng and N. Osman and P. Little},
  journal={The Journal of Pharmacology and Experimental Therapeutics},
  year={2018},
  volume={365},
  pages={156 - 164}
}
Transforming growth factor-β (TGF-β) is a pleiotropic growth factor implicated in the development of atherosclerosis for its role in mediating glycosaminoglycan (GAG) chain hyperelongation on the proteoglycan biglycan, a phenomenon that increases the binding of atherogenic lipoproteins in the vessel wall. Phosphorylation of the transcription factor Smad has emerged as a critical step in the signaling pathways that control the synthesis of biglycan, both the core protein and the GAG chains. We… Expand
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