Flavonoids with an oligopolysulfated moiety: a new class of anticoagulant agents.

  title={Flavonoids with an oligopolysulfated moiety: a new class of anticoagulant agents.},
  author={Marta Correia-da-Silva and Em{\'i}lia Sousa and Barbara P Duarte and Franklim Marques and F{\'e}lix Carvalho and Luis Manuel Cunha-Ribeiro and Madalena M M Pinto},
  journal={Journal of medicinal chemistry},
  volume={54 1},
Polysulfated (oligo)flavonoids were synthesized and assayed for their in vitro and in vivo anticoagulant activities. The approach was based on molecular hybridization of two classes of anticoagulants, sulfated polysaccharides and sulfated flavonoids. The synthesis was optimized using microwave-assisted sulfation with triethylamine-sulfur trioxide. The obtained polysulfated flavonosides were highly effective in increasing clotting times and able to completely block the clotting process, in… CONTINUE READING


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