Flavonoids stimulate Cl conductance of human airway epithelium in vitro and in vivo.

  title={Flavonoids stimulate Cl conductance of human airway epithelium in vitro and in vivo.},
  author={Beate Illek and Horst Fischer},
  journal={The American journal of physiology},
  volume={275 5},
The ability of the flavonoids genistein, apigenin, kaempferol, and quercetin to activate cystic fibrosis transmembrane conductance regulator-mediated Cl currents in human airway epithelium was investigated. We used the patch-clamp technique on single Calu-3 cells, transepithelial measurements in Calu-3 monolayers, and in vivo measurements of nasal potential difference. All flavonoids stimulated Cl currents in transepithelial experiments dose dependently. Half-maximal stimulatory concentrations… 

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