Flavonoids inhibit the formation of the cross-linking AGE pentosidine in collagen incubated with glucose, according to their structure.

@article{Urios2007FlavonoidsIT,
  title={Flavonoids inhibit the formation of the cross-linking AGE pentosidine in collagen incubated with glucose, according to their structure.},
  author={Paul Urios and Anne-Marie Grigorova-Borsos and Michel Sternberg},
  journal={European journal of nutrition},
  year={2007},
  volume={46 3},
  pages={139-46}
}
BACKGROUND Glycoxidation of collagens contributes to development of vascular complications in diabetes. AIM OF THE STUDY Since flavonoids are potent antioxidants present in vegetal foods, it was interesting to examine their effect on the formation of a cross-linking advanced glycation endproduct, pentosidine, in collagens. METHODS Collagen was incubated with glucose (250 mM), in the presence of different flavonoids. Pentosidine was measured by HPLC, hydroxyproline colorimetrically… CONTINUE READING