Flavonoids derived from liquorice suppress murine macrophage activation by up-regulating heme oxygenase-1 independent of Nrf2 activation.

@article{Wang2015FlavonoidsDF,
  title={Flavonoids derived from liquorice suppress murine macrophage activation by up-regulating heme oxygenase-1 independent of Nrf2 activation.},
  author={Rui Wang and Cheng Yue Zhang and Li Ping Bai and Hu Dan Pan and Li Min Shu and David Cheng and Elaine L. Leung and Liang Liu and Ting Li},
  journal={International immunopharmacology},
  year={2015},
  volume={28 2},
  pages={917-24}
}
Liquiritigenin (LQG), isoliquiritin (ILQ) and isoliquiritigenin (ILG) are flavonoids derived from liquorice and all possess a similar chemical structural backbone. In the current study, we found that ILQ and ILG had suppressive effects on lipopolysaccharide (LPS)-induced inflammatory responses in murine macrophage by suppressing the iNOS and COX-2 proteins… CONTINUE READING