Flavonoids as inhibitors of rat liver monooxygenase activities.

  title={Flavonoids as inhibitors of rat liver monooxygenase activities.},
  author={S Beyeler and Bernard Testa and Daniel Perrissoud},
  journal={Biochemical pharmacology},
  volume={37 10},
Flavanone and six hydroxylated derivatives, and cianidanol and eight ethers and esters thereof, were investigated as inhibitors of cytochrome P-450 mediated reactions in rat liver microsomes. The IC50 values towards aminopyrine N-demethylation varied over a 20-fold range and were shown to depend on the pattern of hydroxylation (flavanone derivatives) and on lipophilicity (cianidanol derivatives). In the latter case, a bilinear relationship exists, the optimal log P being 2.92. Using selected… CONTINUE READING

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