Flavonoids as anti-inflammatory agents

@article{Serafini2010FlavonoidsAA,
  title={Flavonoids as anti-inflammatory agents},
  author={Mauro Serafini and Ilaria Peluso and Anna Raguzzini},
  journal={Proceedings of the Nutrition Society},
  year={2010},
  volume={69},
  pages={273 - 278}
}
Epidemiological evidence suggests that a high intake of plant foods is associated with lower risk of chronic diseases. However, the mechanism of action and the components involved in this effect have not been identified clearly. In recent years, the scientific community has agreed to focus its attention on a class of secondary metabolites extensively present in a wide range of plant foods: the flavonoids, suggested as having different biological roles. The anti-inflammatory actions of… 
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References

SHOWING 1-10 OF 70 REFERENCES
Molecular Targets of Dietary Polyphenols with Anti-inflammatory Properties
TLDR
This paper provides an overview of the research approaches that can be used to unravel the biology and health effects of polyphenols and focuses on some of the pivotal molecular targets that directly affect the inflammation process.
Polyphenols, intracellular signalling and inflammation.
TLDR
This review will discuss recent data on the control of inflammatory signalling exerted by some dietary polyphenols contained in Mediterranean diet.
The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer.
TLDR
Western medicine has not yet used flavonoids therapeutically, even though their safety record is exceptional, and suggestions are made where such possibilities may be worth pursuing.
Redox Molecules and Cancer Prevention: The Importance of Understanding the Role of the Antioxidant Network
TLDR
The state of art of the research on TAC and cancer is outlined, describing the plasma non-enzymatic antioxidant network and its association with diet and the feasibility of TAC assessment as an innovative tool for investigating the association between dietary antioxidants, oxidative stress, and cancer.
Pharmacokinetics and metabolism of dietary flavonoids in humans.
TLDR
Differences in absorption, metabolism and pharmacokinetics between the major flavonoids present in the diet are summarized and should be considered in the design and interpretation of studies investigating the mechanisms and potential health effects of Flavonoids.
Polyphenols and disease risk in epidemiologic studies.
Plant polyphenols, a large group of natural antioxidants, are serious candidates in explanations of the protective effects of vegetables and fruits against cancer and cardiovascular diseases.
...
...