Flavonoids are inhibitors of breast cancer resistance protein (ABCG2)-mediated transport.

@article{Zhang2004FlavonoidsAI,
  title={Flavonoids are inhibitors of breast cancer resistance protein (ABCG2)-mediated transport.},
  author={Shuzhong Zhang and Xinning Yang and Marilyn E Morris},
  journal={Molecular pharmacology},
  year={2004},
  volume={65 5},
  pages={1208-16}
}
Breast cancer resistance protein (BCRP) is a newly identified ATP-binding cassette transporter, shown to confer multidrug resistance (MDR) to a number of important anticancer agents and play an important function in governing drug disposition. Flavonoids are a class of polyphenolic compounds widely present in foods and herbal products. The interactions of flavonoids with P-glycoprotein and multidrug resistance-associated protein 1 have been reported; however, their interaction with BCRP is… CONTINUE READING

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