Flavonoids and tyrosine nitration: structure-activity relationship correlation with enthalpy of formation.

@article{Sadeghipour2005FlavonoidsAT,
  title={Flavonoids and tyrosine nitration: structure-activity relationship correlation with enthalpy of formation.},
  author={Mitra Sadeghipour and Raphael Terreux and Jenny Phipps},
  journal={Toxicology in vitro : an international journal published in association with BIBRA},
  year={2005},
  volume={19 2},
  pages={155-65}
}
The ability of 11 flavonoids, naturally occurring polyphenols, and their related structure-activity relationships (SAR's) for inhibiting peroxynitrite-induced nitration of tyrosine was investigated. The flavonoids under study could be classified into four groups having very distinct in vitro inhibition effects. We also calculated the heat of formation (DeltaH(f)) of the corresponding flavonoids radicals which supported this finding. The most effective flavonoids included: catechin, taxifolin… CONTINUE READING
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