Flavonoids and nitric oxide synthase.

@article{Olszanecki2002FlavonoidsAN,
  title={Flavonoids and nitric oxide synthase.},
  author={Rafał Olszanecki and Anna Gębska and Valery I. Kozlovski and Ryszard Jerzy Gryglewski},
  journal={Journal of physiology and pharmacology : an official journal of the Polish Physiological Society},
  year={2002},
  volume={53 4 Pt 1},
  pages={571-84}
}
Induction of NOS-2 in macrophages and smooth muscles within vascular wall with concomittant suppression of endothelial NOS-3 activity is considered to be a hallmark of vascular inflammation that triggers atherogenesis. Accordingly, drugs designed to reverse these changes should not only support vaning function of NOS-3 but also suppress proinflammatory NO production by NOS-2. It means that using selective inhibitors of induction of NOS-2 (they spare ex definitione constitutive activity of NOS-3… CONTINUE READING

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