Flavonoids and cinnamic acid derivatives as inhibitors of 17β-hydroxysteroid dehydrogenase type 1

@article{Broi2009FlavonoidsAC,
  title={Flavonoids and cinnamic acid derivatives as inhibitors of 17β-hydroxysteroid dehydrogenase type 1},
  author={P. Bro{\vz}i{\vc} and P. Kocbek and M. Sova and J. Kristl and T. Rizner},
  journal={Molecular and Cellular Endocrinology},
  year={2009},
  volume={301},
  pages={229-234}
}
  • P. Brožič, P. Kocbek, +2 authors T. Rizner
  • Published 2009
  • Biology, Medicine
  • Molecular and Cellular Endocrinology
  • 17beta-Hydroxysteroid dehydrogenase (17beta-HSD) type 1 converts estrone to estradiol, a potent ligand for estrogen receptors. It represents an important target for the development of drugs for treatment of estrogen-dependent diseases. In the present study, we have examined the inhibitory activities of some flavonoids, their biosynthetic precursors (cinnamic acids and coumaric acid), and their derivatives. The proliferative activity of flavonoids on the T-47D estrogen-receptor-positive breast… CONTINUE READING
    37 Citations
    Environmental pollutants and hydroxysteroid dehydrogenases.
    • 28

    References

    SHOWING 1-10 OF 26 REFERENCES
    Cinnamic acids as new inhibitors of 17β-hydroxysteroid dehydrogenase type 5 (AKR1C3)
    • 38
    Phytoestrogens inhibit human 17β-hydroxysteroid dehydrogenase type 5
    • 139
    • PDF
    Estrogen-Specific 17β-Hydroxysteroid Oxidoreductase Type 1 (E.C. 1.1.1.62) as a Possible Target for the Action of Phytoestrogens
    • 179