Flavonoids and Cancer Prevention: A Review of the Evidence

@article{Romagnolo2012FlavonoidsAC,
  title={Flavonoids and Cancer Prevention: A Review of the Evidence},
  author={D. Romagnolo and O. Selmin},
  journal={Journal of Nutrition in Gerontology and Geriatrics},
  year={2012},
  volume={31},
  pages={206 - 238}
}
The objective of this work is to review data from epidemiological and preclinical studies addressing the potential benefits of diets based on flavonoids for cancer prevention. Flavonoids are subdivided into subclasses including flavonols, flavones, flavanones, flavan-3-ols, anthocyanidins, and isoflavones. Epidemiological studies suggest dietary intake of flavonoids may reduce the risk of tumors of the breast, colon, lung, prostate, and pancreas. However, some studies have reported inconclusive… Expand

Paper Mentions

Intake of Individual Flavonoids and Risk of Carcinogenesis: Overview of Epidemiological Evidence
  • K. Sak
  • Medicine
  • Nutrition and cancer
  • 2017
TLDR
Further large-scale prospective studies with longer follow-up times, different populations, various doses and exposure timing as well as diverse well-controlled confounders are highly needed to confirm or disprove the current epidemiological knowledge about the role of flavonoids on cancer risk. Expand
Flavonoid-Based Cancer Therapy: An Updated Review.
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The main aim of this review is to evaluate the relationship between flavonoids consumption and cancer risk, and discus the anti-cancer effects of these natural compounds in human cancer cells. Expand
Epigenetic activities of flavonoids in the prevention and treatment of cancer
TLDR
An overview of current research on flavonoids is given to further elucidate their potential in cancer prevention and therapy, thereby focusing on their distinct epigenetic activities. Expand
Flavan-3-ols consumption and cancer risk: a meta-analysis of epidemiologic studies
TLDR
A meta-analysis of epidemiologic studies to investigate the preventive effects of flavan-3-ols on various types of cancers indicates the potential benefits of Flavan- 3-ols in cancer prevention. Expand
Dietary flavonoid intake and colorectal cancer risk in the European prospective investigation into cancer and nutrition (EPIC) cohort
TLDR
Intake of total flavonoids and flavonoid subclasses, as estimated from dietary questionnaires, did not show any association with risk of CRC development and similar results were observed for flavonoidal intake expressed as glycosides or aglycone equivalents. Expand
Dietary Flavonoid Intake and Thyroid Cancer Risk in the NIH–AARP Diet and Health Study
TLDR
Thyroid cancer risk was inversely associated with dietary flavan-3-ols, but positively associated with flavanones, and other classes of flavonoid and total flavonoids were not associated with thyroid cancer risk. Expand
Flavonoids intake and risk of prostate cancer: a meta‐analysis of observational studies
TLDR
Higher intake of flavonoids may not be associated with prostate cancer risk, according to a meta‐analysis of five studies including four prospective cohort studies and one case–control study. Expand
Flavonol Regulation in Tumor Cells
  • M. Lea
  • Biology, Medicine
  • Journal of cellular biochemistry
  • 2015
TLDR
Therapeutic potential of flavonols is indicated by their growth inhibitory action accompanied by a decrease in several hallmarks of cancer such as resistance to apoptosis, and many investigators are sufficiently encouraged by past observations that they are responding to the challenge to optimize the dietary and therapeutic use of Flavonols in cancer prevention and treatment. Expand
Targeting epigenetics in cancer: therapeutic potential of flavonoids
TLDR
This review focuses on plant-derived flavonoids as a therapeutic tool for cancer, attributed to their ability for epigenetic regulation of cancer pathogenesis, and the epigenetic mechanisms of various classes of flavonoid. Expand
Enzymatic Metabolism of Flavonoids by Gut Microbiota and Its Impact on Gastrointestinal Cancer
Simple Summary Flavonoid’s consumption is reported to impact GI cancer progression positively. As 90% of flavonoids consumed, undergo metabolism and conversion by the human gut microbiome,Expand
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