Flavonoids Suppress Pseudomonas aeruginosa Virulence through Allosteric Inhibition of Quorum-sensing Receptors.

@article{Paczkowski2017FlavonoidsSP,
  title={Flavonoids Suppress Pseudomonas aeruginosa Virulence through Allosteric Inhibition of Quorum-sensing Receptors.},
  author={Jon E Paczkowski and Sampriti Mukherjee and Amelia R McCready and J P Cong and Christopher J Aquino and Hahn Kim and Brad R Henke and Chari D Smith and Bonnie L Bassler},
  journal={The Journal of biological chemistry},
  year={2017},
  volume={292 10},
  pages={4064-4076}
}
Quorum sensing is a process of cell-cell communication that bacteria use to regulate collective behaviors. Quorum sensing depends on the production, detection, and group-wide response to extracellular signal molecules called autoinducers. In many bacterial species, quorum sensing controls virulence factor production. Thus, disrupting quorum sensing is considered a promising strategy to combat bacterial pathogenicity. Several members of a family of naturally produced plant metabolites called… CONTINUE READING
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