Flavonoid quercetin decreases osteoclastic differentiation induced by RANKL via a mechanism involving NF kappa B and AP-1.

@article{Wattel2004FlavonoidQD,
  title={Flavonoid quercetin decreases osteoclastic differentiation induced by RANKL via a mechanism involving NF kappa B and AP-1.},
  author={Alice Wattel and Said Kamel and Christophe Prouillet and Jean-Pierre Petit and Florence Lorget and Elizabeth Offord and Michel Brazier},
  journal={Journal of cellular biochemistry},
  year={2004},
  volume={92 2},
  pages={285-95}
}
Flavonoids are micronutrients widely present in food of plant origin. They have been attributed pharmacological properties such as anticancer and prevention of age-related pathologies. It has been recently hypothesized that flavonoids increase bone mass and prevent osteoporosis. However, little is known about the in vitro effects of flavonoids on osteoclast activities. We investigated the effects of quercetin, one of the most commonly occurring flavonoids, on osteoclast differentiation which is… CONTINUE READING

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