Flavonoid quercetin–methotrexate combination inhibits inflammatory mediators and matrix metalloproteinase expression, providing protection to joints in collagen-induced arthritis

@article{Haleagrahara2018FlavonoidQC,
  title={Flavonoid quercetin–methotrexate combination inhibits inflammatory mediators and matrix metalloproteinase expression, providing protection to joints in collagen-induced arthritis},
  author={Nagaraja Haleagrahara and Kelly A. Hodgson and Socorro Miranda-Hernandez and Samuel Hughes and Anupama Bangra Kulur and Natkunam Ketheesan},
  journal={Inflammopharmacology},
  year={2018},
  volume={26},
  pages={1219-1232}
}
Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation of synovial tissues in joints, leading to progressive destruction of cartilage and joints. The disease-modifying anti-rheumatic drugs currently in use have side-effects. Thus, there is an urgent need for safe anti-inflammatory therapies for RA. This study aimed to evaluate the therapeutic effect of the flavonoid quercetin on arthritis in mice immunized with type II collagen (CII). An arthritis model was… Expand
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