Flavonoid-mediated presenilin-1 phosphorylation reduces Alzheimer's disease β-amyloid production

  title={Flavonoid-mediated presenilin-1 phosphorylation reduces Alzheimer's disease β-amyloid production},
  author={Kavon Rezai-zadeh and R Douglas Shytle and Yun Bai and Jun Tian and Huayan Hou and Takashi Mori and Jin Zeng and Demian F. Obregon and Terrence C. Town and Jun Tan},
  booktitle={Journal of cellular and molecular medicine},
Glycogen synthase kinase 3 (GSK-3) dysregulation is implicated in the two Alzheimer's disease (AD) pathological hallmarks: beta-amyloid plaques and neurofibrillary tangles. GSK-3 inhibitors may abrogate AD pathology by inhibiting amyloidogenic gamma-secretase cleavage of amyloid precursor protein (APP). Here, we report that the citrus bioflavonoid luteolin reduces amyloid-beta (Abeta) peptide generation in both human 'Swedish' mutant APP transgene-bearing neuron-like cells and primary neurons… CONTINUE READING
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