Flavonoid genistein protects bone marrow sinusoidal blood vessels from damage by methotrexate therapy in rats

@article{Hassanshahi2019FlavonoidGP,
  title={Flavonoid genistein protects bone marrow sinusoidal blood vessels from damage by methotrexate therapy in rats},
  author={M. Hassanshahi and Y. Su and S. Khabbazi and C. Fan and Ke-Ming Chen and Ju-fang Wang and A. Qian and P. Howe and D. Yan and H. Zhou and C. Xian},
  journal={Journal of Cellular Physiology},
  year={2019},
  volume={234},
  pages={11276 - 11286}
}
  • M. Hassanshahi, Y. Su, +8 authors C. Xian
  • Published 2019
  • Medicine, Biology
  • Journal of Cellular Physiology
  • Cancer chemotherapy can cause significant damage to the bone marrow (BM) microvascular (sinusoidal) system. Investigations must now address whether and how BM sinusoidal endothelial cells (SECs) can be protected during chemotherapy. Herein we examined the potential protective effects of genistein, a soy‐derived flavonoid, against BM sinusoidal damage caused by treatment with methotrexate (MTX). The groups of young adult rats were gavaged daily with genistein (20 mg/kg) or placebo. After 1 week… CONTINUE READING

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