Flavonoid genistein protects bone marrow sinusoidal blood vessels from damage by methotrexate therapy in rats

  title={Flavonoid genistein protects bone marrow sinusoidal blood vessels from damage by methotrexate therapy in rats},
  author={Mohammadhossein Hassanshahi and Yu‐wen Su and Samira Khabbazi and Chiaming Fan and Ke-Ming Chen and Ju-Fang Wang and Airong Qian and Peter R. C. Howe and De-wen Yan and Hou-de Zhou and Cory J. Xian},
  journal={Journal of Cellular Physiology},
  pages={11276 - 11286}
Cancer chemotherapy can cause significant damage to the bone marrow (BM) microvascular (sinusoidal) system. Investigations must now address whether and how BM sinusoidal endothelial cells (SECs) can be protected during chemotherapy. Herein we examined the potential protective effects of genistein, a soy‐derived flavonoid, against BM sinusoidal damage caused by treatment with methotrexate (MTX). The groups of young adult rats were gavaged daily with genistein (20 mg/kg) or placebo. After 1 week… Expand
Icariin attenuates methotrexate chemotherapy‐induced bone marrow microvascular damage and bone loss in rats
In vitro studies suggest that icariin treatment can potentially enhance the survival of cultured rat sinusoidal endothelial cells against cytotoxic effect of MTX and promote their migration and tube formation abilities, which is associated with enhanced production of nitric oxide. Expand
Roles of apoptotic chondrocyte‐derived CXCL12 in the enhanced chondroclast recruitment following methotrexate and/or dexamethasone treatment
An association between induced chondrocyte apoptosis and stimulated osteoclastic migration and formation following MTX and/or DEX treatment, which could be potentially or at least partially linked molecularly by CXCL12 induction is shown. Expand
Bone marrow sinusoidal endothelium as a facilitator/regulator of cell egress from the bone marrow.
The current review suggests that the BM SECs may not be merely a neutral gatekeeper for cell intravasation and extravasation, but rather is a dynamic trafficking surveillance system, thereby the process of BM cell egress/mobilisation can be regulated. Expand
Genistein protects intervertebral discs from degeneration via Nrf2‐mediated antioxidant defense system: An in vitro and in vivo study
This study suggests that GES exerts protective effects in NPCs against degeneration and reveals the underlying mechanism of GES on Nrf2 activation in NPCs. Expand
Dual drugs release from nanoporously bioactive coating on polyetheretherketone for enhancement of antibacterial activity, rBMSCs responses and osseointegration
Abstract A bioactive coating of nanoporous magnesium calcium silicate (n-MCS) on polyetheretherketone (ncPK) surface was prepared, and dual drugs of genistein (GS) and curcumin (CR) were co-loadedExpand
Critical limb ischemia: Current and novel therapeutic strategies
The benefits and disadvantages of current therapeutic strategies for CLI treatment are addressed, novel and promising therapeutic approaches such as proangiogenic gene/protein therapies and stem cell‐based therapies are summarized, and these novel CLI therapeutic strategies show considerable advantages to be used when current conventional methods have failed. Expand
marrowmicrovascular damage and bone loss in rats
  • 2019


Supplementation with Fish Oil and Genistein, Individually or in Combination, Protects Bone against the Adverse Effects of Methotrexate Chemotherapy in Rats
Fish oil and/or genistein supplementation during MTX treatment enabled not only preservation of osteogenic differentiation, osteoblast number and bone volume, but also prevention ofMTX treatment-induced increases in bone marrow adiposity, osteoclastogenic cytokine expression and osteoc last formation, and thus bone loss. Expand
Potential Effects of Phytoestrogen Genistein in Modulating Acute Methotrexate Chemotherapy-Induced Osteoclastogenesis and Bone Damage in Rats
This study suggests that genistein may suppress MTX-induced osteoclastogenesis; however, further studies are required to examine its potential in protecting against MTX chemotherapy-induced bone damage. Expand
Methotrexate chemotherapy–induced damages in bone marrow sinusoids: An in vivo and in vitro study
The data from this study indicates that methotrexate can cause significant bone marrow sinusoidal endothelium damage in vivo and induce apoptosis and inhibit proliferation, migration and tube‐forming abilities of sinusoid endothelial cells in vitro. Expand
Cellular mechanisms for methotrexate chemotherapy-induced bone growth defects.
Observations suggest that methotrexate chemotherapy may cause bone growth defects by arresting cellular activities in the growth plate in producing calcified cartilage and primary trabecular bone and by decreasing pools of metaphyseal osteoblastic cells. Expand
Bone marrow sinusoidal endothelium: damage and potential regeneration following cancer radiotherapy or chemotherapy
It is very well known that bone marrow (BM) microvasculature may possess a crucial role in the maintenance of homeostasis of BM due to mutual interactions between BM microvascular system and otherExpand
Genistein accelerates refractory wound healing by suppressing superoxide and FoxO1/iNOS pathway in type 1 diabetes.
Genistein rescued the delayed wound healing and improved wound angiogenesis in STZ-induced type 1 diabetes in mice, at least in part, by suppression of FoxO1, iNOS activity and oxidative stress. Expand
The effect of the phytoestrogen genistein on metabolism of bones in ovariectomy rats and IL-6 in celiac macrophages of mice
The results indicated that genistein could restrain body weight, increase the levels of serum Ca,Mg,P,calcitonin(CT) and decrease the Levels of bone gla protein (BGP) and alkaline phosphatase (ALP) significantly and meliorate biomechanical indexes of rats. Expand
[Effects of genistein on the fenestrae, proliferation and nitric oxide synthesis of liver sinusoidal endothelial cells from carbon tetrachloride-induced experimental hepatic fibrosis rats].
The results suggest that genistein may play an important role in regulating the function of SECs, and the number of fenestrae in SECs from all stage of hepatic fibrotic rats was decreased markedly as compared with theSECs from normal controls. Expand
Genistein Promotes Endothelial Colony-Forming Cell (ECFC) Bioactivities and Cardiac Regeneration in Myocardial Infarction
Taken together, data suggest that pretreatment of ECFCs with genistein prior to transplantation can improve the regenerative potential in ischemic tissues, providing a novel strategy in adult stem cell therapy for isChemic diseases. Expand
Anti-angiogenic genistein inhibits VEGF-induced endothelial cell activation by decreasing PTK activity and MAPK activation
It is suggested that the inhibition of PTK activity and MAPK activation and the decrease in MMPs production and activity by genistein interrupt VEGF-stimulated endothelial cell activation, which thereby may represent a mechanism that would explain the anti-angiogenesis effect of Gen and its cancer-protective function. Expand