Flavonoid genistein protects bone marrow sinusoidal blood vessels from damage by methotrexate therapy in rats

@article{Hassanshahi2019FlavonoidGP,
  title={Flavonoid genistein protects bone marrow sinusoidal blood vessels from damage by methotrexate therapy in rats},
  author={Mohammadhossein Hassanshahi and Yu‐wen Su and Samira Khabbazi and Chiaming Fan and Ke-Ming Chen and Ju-Fang Wang and Airong Qian and Peter R. C. Howe and De-wen Yan and Hou-de Zhou and Cory J. Xian},
  journal={Journal of Cellular Physiology},
  year={2019},
  volume={234},
  pages={11276 - 11286}
}
Cancer chemotherapy can cause significant damage to the bone marrow (BM) microvascular (sinusoidal) system. Investigations must now address whether and how BM sinusoidal endothelial cells (SECs) can be protected during chemotherapy. Herein we examined the potential protective effects of genistein, a soy‐derived flavonoid, against BM sinusoidal damage caused by treatment with methotrexate (MTX). The groups of young adult rats were gavaged daily with genistein (20 mg/kg) or placebo. After 1 week… Expand
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marrowmicrovascular damage and bone loss in rats
  • 2019

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Supplementation with Fish Oil and Genistein, Individually or in Combination, Protects Bone against the Adverse Effects of Methotrexate Chemotherapy in Rats
TLDR
Fish oil and/or genistein supplementation during MTX treatment enabled not only preservation of osteogenic differentiation, osteoblast number and bone volume, but also prevention ofMTX treatment-induced increases in bone marrow adiposity, osteoclastogenic cytokine expression and osteoc last formation, and thus bone loss. Expand
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TLDR
This study suggests that genistein may suppress MTX-induced osteoclastogenesis; however, further studies are required to examine its potential in protecting against MTX chemotherapy-induced bone damage. Expand
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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